Studies on the superoxide generating system, superoxide dismutase and lipoperoxide in rheumatoid arthritis

Leucocyte superoxide dismutase in rheumatoid arthritis.

Superoxide dismutase (SOD) activity was measured in polymorphonuclear leucocytes (PMNLs) and mononuclear cells (MNCs) from 60 patients with rheumatoid arthritis (RA) and in 15 controls. In all patients and controls SOD activity (U/mg protein) in MNCs was twice that in PMNLs. SOD activity in PMNLs and in MNCs from patients with RA was significantly higher than that in controls. SOD activity in P...

Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.

Serum copper and thiol levels an caeruloplasmin activity were determined and compared with measurements of articular index, erythrocyte sedimentation rate, and zinc and haemoglobin levels in patients with rheumatoid arthritis. Superoxide dismutase activity, thiol, zinc, and copper levels of haemolysate were measured and compared with each other and to the above parameters. In serum, caeruloplas...

Inhibitory effect of superoxide-generating quinones on superoxide dismutase.

The one-electron reduction of quinones to semiquinones and the subsequent autooxldatlon of the semlqulnone back to the quinone can generate large quantities of superoxide (0~) (1,2). This reductlon-oxldation process, known as redox cycling, is anion radical catalyzed by a variety of cellular flavoproteins and is thought to be responsible for many of the therapeutic and toxic effects of quinonoi...

Superoxide dismutase Superoxide dismutase

Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides.

The activity of superoxide dismutase isoenzymes was determined in knee joint synovial fluid from 21 patients with rheumatoid arthritis, nine patients with reactive arthritides, and from 17 patients before arthroscopy or arthrotomy for suspected meniscal or ligament injury (controls). Extracellular superoxide dismutase was the major isoenzyme and accounted for about 80% of the total superoxide d...